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In the REDEFINE 1 trial, 79.6% of combination participants experienced GI events versus 39.9% on placebo

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In some cases, people with low platelet counts may even faint due to excessive bleeding

Fourth, long-term clinical outcomes data - cirrhosis incidence, HCC rates, liver transplantation, and liver-related mortality assessed as primary endpoints in randomized trials - are not yet available and are urgently needed to move beyond surrogate histological endpoints