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Once in the extracellular space, mtDNA is recognized by TLR9 in endosomes of dendritic cells, macrophages, and B-cells, triggering MyD88-dependent NF-B activation and a burst of pro-inflammatory cytokines like IL-6, TNF-
Cells were incubated with QIs or parent compounds for 2.5 h, based on the time-dependency of QIs-induced loss of cell viability (Supplementary Figure S3)
Dalhoff K
Skin bio -peels
Mol Neurobiol 62:36533672
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