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The standard cagrilintide monotherapy titration follows this schedule: 0.25 mg weekly for weeks 1-4, then 0.5 mg for weeks 5-8, then 1.0 mg for weeks 9-12, then 1.7 mg for weeks 13-16, and finally 2.4 mg for week 17 onward as the maintenance dose

Schedule: Weekly subcutaneous injection on the same day each week for 1216+ weeks

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Jamshed 2011): rectal bleeding positive occult blood (microscopic traces of blood in the stool) iron-deficiency anemia unintended weight loss of 10 pounds or more symptoms of obstruction recent onset of symptoms (especially in an older individual) rectal prolapse change in stool diameter family history of colon cancer age older than 50 8 Conventional Treatment First-line treatment for uncomplicated primary constipation is to ensure adequate dietary fiber and fluid intake and physical activity level (Rao 2014