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Below pH 5.0, protonation of the histidine imidazole group disrupts copper coordination, causing copper dissociation and destabilization
These observations come primarily from controlled laboratory experiments rather than clinical applications
Namely, it is always applied alone (Sikiric et al., 1993
The enzyme methionine synthase then uses methylcobalamin to convert homocysteine into methionine
First, a little primer on B12: B12 is water-soluble, so any excess is urinated out
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