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: 11.1146/annurev.nu.06.070186.000353

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J Inflammation Res (2020) 13:51931

CNS-Mediated Sexual Arousal PT-141's primary studied effect is the activation of MC4R receptors in hypothalamic regions of the brain specifically the medial preoptic area and paraventricular nucleus that are associated with sexual arousal and motivation

Microdosing is particularly appropriate for older adults because it allows for slow, careful dose escalation that minimizes the risk of dehydration (from nausea and reduced fluid intake), excessive muscle catabolism (from rapid caloric deficit), and medication interactions (which become more common with polypharmacy in older populations)