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The review confirmed that NNMT-mediated NAD+ depletion impairs mitochondrial function, SIRT activity (particularly SIRT1 and SIRT3), redox balance, and energy metabolism, creating conditions relevant to cardiovascular disease research models
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10.1016/j.drugpo.2023.104139 42 PoplawskaM.BednarekE.NaumczukB.BlazewiczA
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