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Effect of nitric oxide on lymphocytes from sporadic amyotrophic lateral sclerosis patients: toxic or protective role

When faced with such a prospect, a 24-h clear liquid diet does not seem to pose an equal risk or inconvenience. The bottom line is this: the most risk-mitigating approach based on the evidence would be to have patients fast for longer (ideally no solids for 24 hours and no liquids for perhaps longer than 2 hours)

doi: 10.1093/toxsci/51.2.161

In fasted states, including ALS, skeletal muscles increase utilization of fatty acid oxidation, which in turn reduces glucose metabolism [304, 305]