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Acta Pharmacol Sin 33:7581

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These compounds may contribute to overall physiological adaptations beyond tissue development and compositional changes

Besides their special organization in lipid domains (lipid rafts) of the membrane lipid bilayers, some sphingolipids, e.g., ceramides, sphingosine, and sphingosine-1-phosphate have been described to function as lipid-derived second messengers mainly regulating fundamental cellular pathways such as apoptosis and differentiation [119, 120]

Neurochemistry international, 2019, 128, 94105