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174 Interestingly, some emerging evidence suggests protein restriction may not be as important for patients being treated with RAAS inhibitors and SGLT2 inhibitors, and several leading guidelines do not recommend any protein restriction for people with CKD, although excess protein intake is often discouraged

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Dual action also made protocols more complex

Clinical data from the STEP and SURMOUNT trials showed lean body mass comprising 26% to 40% of total weight lost