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These agents exhibit anti-inflammatory, cardioprotective, and neuroprotective effects, suggesting a broader therapeutic potential

A 2021 study demonstrated that the antibodies present in fibromyalgia patients cause painful hypersensitivity to cold and mechanical stimulation by sensitizing nociceptive (pain-sensing) nerve fibers

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For recycling, cells were incubated with agonists at 37 C for 15 min, followed by endocytosis arrest at 4 C, surface label removal as above, 30 min incubation at 37 C with 10 M exendin(9-39) to prevent further internalization, and a second round of surface label removal at 4 C