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Exercise helps preserve muscle mass during weight loss, which is critical given that up to 40% of GLP-1-related weight loss can come from lean tissue without proper intervention
This is fundamentally different from hormone replacement and is why it has a cleaner side effect profile than direct HGH
Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin
SURMOUNT-2 (N=938), conducted in patients with type 2 diabetes and obesity, showed 14.7% weight loss with tirzepatide 15 mg versus 3.2% with placebo, along with a 2.1 percentage point reduction in A1C [15]
Granata A, Maccarrone R, Anzaldi M, Leonardi G, Pesce F, Amico F, et al
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