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Lancet 374:16061616 DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD (2005) Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes

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These results supported the hypothesis that an early multi-targeting approach in PCOS may be more effective and may allow the use of low-dose regimens, thus improving both the safety and the tolerability of the treatment and reducing costs