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(Indeed, theres a principle that specifically opposes Occams razor in the context of medicineHickams dictum, which is typically presented as the observation that a patient can have as many diseases as they damn well please.) So although defaulting to the simplest explanation may make sense when all else is equal, biology is often far more complex than we predict, and therefore, we need to be ready to abandon or revise the simpler theory when presented with new information
Maretty L, Gill D, Simonsen L, Soh K, Zagkos L, Galanakis M, Sibbesen J, Iglesias MT, Secher A, Valkenborg D, Purnell JQ, Knudsen LB, Tahrani AA, Geybels M (2025) Proteomic changes upon treatment with semaglutide in individuals with obesity
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