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The triad model was selected as the final model as the comproportionation reaction ( R 5 ) parameters ( k p5 and k m5 ) were the two least sensitive parameters with respect to model OCR output for both main and total effects during global sensitivity analysis (Fig
Mitochondrial DNA variation in extremely selected traits: longevity and elite athletic performance
Thus, a great deal of evidence supports the clinical potential of using intranasal delivery of BDNF because (1) there is a large surface area for drug absorption through the nasal mucosa, (2) intranasal delivery bypasses the BBB, (3) the needle-free and easy self-administration improves patients compliance, (4) it enables both rapid and direct CNS delivery of BDNF with high bioavailability by avoiding first-pass hepatic clearance, (5) it causes minimal systemic exposure, (6) a small dosage can be used, avoiding adverse effects, and (7) no drug modification is required
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