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Although the actions of GLP-1 on the beta-cell are preserved yet modestly diminished in T2DM, the diabetic alpha-cell retains near normal responsivity to low dose GLP-1 infusion, with inhibition of glucagon secretion seen to a similar extent in diabetic vs
Abdulmalek SA, Balbaa M (2019) Synergistic effect of nano-selenium and metformin on type 2 diabetic rat model: diabetic complications alleviation through insulin sensitivity, oxidative mediators and inflammatory markers
Competition is expected to intensify as new oral options and additional manufacturers enter the category, and most analysts expect downward pressure on net prices as that happens
However, outside of this specific orphan condition, no strong human evidence exists
Gradual titration often helps reduce them
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