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It is worth to mention that available reports describing the encapsulation of GSH- or albumin-protected AuNCs are limited to hydrophilic, rather than hydrophobic, matrices such as nanogels 25 , aqueous core of microcapsules 26 , silica nanoparticles, protein nanoparticles 27,28 , polymer nanoparticles 29,30 and metal-organic frameworks 31

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Applying ice, resting the area, and following provider instructions can help minimize irritation while the medication begins working

You may feel a slight pinch with needle insertion and / or burning sensation

The most frequently reported reactions include: Redness (erythema) at the application site Itching or a tingling/stinging sensation , especially on freshly exfoliated or compromised skin Dryness or mild flaking , sometimes related to the overall formulation rather than the peptide itself Temporary irritation when combined with strong actives These reactions typically resolve on their own or after reducing frequency of use