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Jaggard JB, Stahl BA, Lloyd E, Prober DA, Duboue ER, Keene AC (2018) Hypocretin underlies the evolution of sleep loss in the Mexican cavefish

Subfamilies and isoforms can be categorized based on the sequence similarity, domain architecture, quaternary structure, enzymatic activity, ironsulfur cluster binding and the number of active site cysteine residues 1,2,3,4,5

While efficacy endpoints for weight loss in those trials were modest, the compound exhibited a favorable safety profile, supporting its later GRAS designation for food use

10.3389/fimmu.2021.652782 110 WeiM.ZhengZ.ShiL.JinY.JiL

demonstrated that combination of NaB, Parnate, and RG108 with a Wnt signaling activator significantly reprogrammed MEFs into multipotent progenitor cells with transient expression of three transcription factors (OCT4, SOX2 and KLF4) (Zhu et al., 2014)