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Combined with clinical assessment of GI function, weight-loss history, and tolerance, genetic insights contribute to a comprehensive, personalized treatment plan rather than trial-and-error dosing

Consider increased clinical or laboratory monitoring for medications that have a narrow therapeutic index or that require clinical monitoring Use in Specific Populations Pregnancy: Available data with semaglutide use in pregnant women are not sufficient to determine a drug associated risk for major birth defects, miscarriage, or other adverse maternal or fetal outcomes

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Reports have surfaced of nervous system problems, and since there are no consistent quality standards for these treatments, the risks are unpredictable

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