does the glp 1 really work UC Davis Health examines systemic impact of GLP-1–based therapies Why GLP-1 Drugs Alone Aren't

N., Dua, S

A BMI of 27 or higher and have one of these conditions: prediabetes, a history of heart attack, stroke or peripheral artery disease

Alternative GLP-1 agent: Switching to a different GLP-1 receptor agonist with different pharmacokinetic properties may be beneficial, as individual patient responses vary

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GLP-1 receptor agonists reduce energy intake by up to roughly 40%, according to a 2025 review of the evidence, and they do it through three overlapping pathways: appetite suppression, delayed gastric emptying, and altered nutrient absorption