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Vitamin B12 is essential for normal blood formation, cellular metabolism, and neurological function

The NHS notes that adults need only around 1.5 micrograms a day, which a normal mixed diet covers with ease

When B12 levels are low, oxygen delivery and energy metabolism can be affected, leaving you feeling tired or sluggish

see NHS guidance and Xenical/Alli SmPCs), and injectable GLP-1 receptor agonists such as semaglutide (Wegovy) and liraglutide (Saxenda)

Whilst these compounds have established biochemical functions, there is no robust randomised controlled trial evidence for clinically meaningful weight loss or fat reduction in replete individuals