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1 Mitochondrial physiology and mitochondrial diseases Mitochondria, essential organelles in eukaryotic cells, produce energy by generating adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS)

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The Biochemical Relationship (Simplified) NAD+ metabolism produces NADPH NADPH is required to keep glutathione in its active (reduced) form Active glutathione neutralizes oxidative stress Reduced oxidative stress helps preserve NAD+ levels In other words: NAD+ helps keep glutathione working

As NEM can react and thus consume partial thiols, less amount of thiol is available for TPE-DCV to react

And actually to that point, one thing I really love about how we do the show together with the format, because we came up with the idea of alternating and like one of us doing a study each week