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As a proof-of-concept, we used DL-buthionine-(S,R)-sulfoximine (BSO) to inhibit GSH biosynthesis in Akita mice, which are prone to proinsulin misfolding
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In another rat model of ischemic stroke, liraglutide treatment promoted neurovascular remodeling in cerebral ischemic areas, through induction of angiogenesis and an increase in neural cell activity [67]
Mohs RC, Davis KL, Tinklenberg JR, Hollister LE
CPT1A can also protect cells from apoptosis by clearing the cytoplasmic long-chain fatty acyl-CoA such as palmitoyl-CoA, and thus impede the production of palmitate/palmitoyl-CoA/ceramide involved in the apoptosis pathway activation 31
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