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For example, a healthy person taking a 500 mcg oral B12 supplement will only absorb about 10 mcg

Progressive destruction of the cells that line the stomach causes decreased secretion of acid and enzymes required to release food-bound vitamin B 12 (5)

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Researchers studying NAD+ biology or methyl-donor pools should evaluate primary sources directly and note that NNMT inhibition has distinct mechanistic implications compared to direct NAD+ precursor supplementation with molecules like NMN or NAD+ itself