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As a chronic, multifactorial disease, obesity warrants the same clinical rigor in diagnosis, monitoring, and treatment as other chronic conditions such as dyslipidemia or type 2 diabetes mellitus ( Our findings support the consideration of pharmacological therapy as a component of pediatric obesity management when lifestyle interventions alone fail to achieve clinically meaningful outcomes

Taken together, the data in the literature indicate that GLP-1R signaling in ARC may be a major contributor to the homeostatic effects of GLP-1 analogs on feeding, whereas other brain regions such as the brainstem may play a minor role

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Cost sensitivity influences treatment duration, adherence rates, and prescribing decisions