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Resolving GLP-1-related constipation through fiber supplementation, hydration, magnesium, and physical activity can produce a dramatic "drop" on the scale that represents the unmasking of fat loss that was happening all along
For patients evaluating blood sugar management options, understanding the mechanistic gap between natural supplements and prescription-strength GLP-1 agonists is critical
What would change my view A well-designed randomized controlled trial directly comparing at-home microinfusion at 0.5mm with a multi-peptide serum against topical application of the same serum without the device, with VISIA or similar objective imaging at 12 and 24 weeks, would be the cleanest piece of evidence the category currently lacks
JAMA, 331 (1), 38-48
Outcomes vary widely by patient
