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Sources: Sikiric P, Seiwerth S, Rucman R, et al
[33], dulaglutide managed to significantly reduce AGEs levels in the peripheral blood, and consequently inhibit ROS production, oxidative damage and production of proinflammatory mediators, such as IL-6, TNF-a and CRP (Fig
62 In the first few hours, 20% of the drugs total elimination or if the drugs primary target organ is the liver
This potentially leads to limitations in GLP-1 receptor agonist use in patients who are unwilling or unable to administer these medications subcutaneously
Nishimura R et al
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