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DOI: 10.1016/0024-3205(96)00160-9 ScienceDirect Wessells H i wsp

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Brand-Name Medication Costs (Without Insurance): Semaglutide (Wegovy/Ozempic): List Price: $1,349 per month With Manufacturer Coupon: May reduce to $25/month with commercial insurance (not available for Medicare/Medicaid or cash-pay patients) Average With Insurance: $25-$300 per month depending on coverage Availability: Ongoing shortages affecting access Tirzepatide (Zepbound/Mounjaro): List Price: $1,069 per month With Manufacturer Coupon: May reduce to $25/month with commercial insurance (not available for Medicare/Medicaid or cash-pay patients) Average With Insurance: $25-$300 per month depending on coverage Availability: Better availability than semaglutide, though still limited Compounded Medication Costs: Compounded Semaglutide: TrimRx: $199/month with annual commitment Other Providers: $199-$599/month Insurance: Not covered HSA/FSA: Usually eligible Savings vs Brand-Name: $1,150/month ($13,800/year) Compounded Tirzepatide: TrimRx: $349/month with annual commitment Other Providers: $349-$699/month Insurance: Not covered HSA/FSA: Usually eligible Savings vs Brand-Name: $720/month ($8,640/year) Annual Cost Comparison: Cost vs Effectiveness Analysis: Compounded Options: For the $150/month price difference ($1,800/year) between compounded semaglutide and tirzepatide: You get approximately 7.6% more weight loss on average For a 250-pound person, thats about 19 additional pounds lost Cost per additional pound lost: ~$95 Is the Extra Cost Worth It