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757772, 2012 [10] E

J Clin Oncol 32(30):3400-5, 2014

Even with safety monitoring systems like the UKs Medicines and Healthcare products Regulatory Agency (MHRA) logging hundreds of reported cases over time, no direct causal relationship has been confirmed

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The mechanisms that may contribute to the induction of oxidative damage in diabetic patients include hyperglycemia-induced glucose auto-oxidation, non-enzymatic glycation of proteins and lipids, increased sorbitol pathway activity, oxidation of AGEs, and formation of prostaglandin H2 (PGH2) [311]