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New England Journal of Medicine (2025) The REDEFINE 1 Phase 3 trial was a landmark 68-week, double-blind, randomized study comparing CagriSema (cagrilintide 2.4 mg plus semaglutide 2.4 mg) with semaglutide alone, cagrilintide alone, and placebo in 3,417 adults with obesity or overweight without diabetes
While its primary action involves p53 release, the modulation of FOXO4-related pathways intersects with cellular stress-response systems
Storage & handling Store the sealed lyophilized powder at 20 C, protected from light and moisture
That is a remarkable safety record
Many patients use both together
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