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Key limitation: With only 3 patients per group, even a single unusually responsive or non-responsive patient could substantially skew the results

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[56] [57] Economic evaluations of GLP-1 receptor agonists for non-diabetic obesity have reported incremental cost-effectiveness ratios well above common willingness-to-pay thresholds, including estimates in the approximate range of $237,000-$483,000 per quality-adjusted life-year in some U.S.-based models

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