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For consumers and athletes, the message is clear: these substances carry unknown risks, lack safety data, and have no legitimate place in dietary supplements or cognitive enhancement products despite their availability online

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Patients receiving sitagliptin with metformin and glimepiride had significant improvements in A1C and FPG compared to patients receiving placebo with metformin and glimepiride (Table 11), with mean reductions from baseline relative to placebo in A1C of -0.9% and in FPG of -21 mg/dL