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During the significant caloric restriction that often accompanies tirzepatide therapy , maintaining adequate B12 levels helps prevent the profound fatigue that can derail a weight loss program
The primary endpoints that track response to MOTS-c therapy align with the peptide's core mechanisms: insulin sensitivity, mitochondrial function, body composition, and inflammatory tone
Additionally, its effects on gut motility and bowel function mean it warrants caution in patients with bowel obstruction or severe gastrointestinal surgery history
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