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GLP-1 medications provide significant heart protection by reducing inflammation, improving cholesterol profiles, and lowering the risk of heart failure and stroke

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Acidic pH impairs the activity of the mitochondrial L-2-HG removal enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH) and enhances the protein stabilization of HIF-1, leading to its escape from the degradation pathway 90

When MPC is additionally blocked, glutamine is rerouted through glutamate dehydrogenase (GDH) to furnish acetyl-coenyzme A (CoA) and oxaloacetate for the tricarboxylic acid cycle (TCA) cycle

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