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This sustained genotoxic stress depletes the mismatch repair (MMR) system, resulting in microsatellite instability (MSI) phenotypes and conferring a high mutation burden on cells (103)

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Li F, Jiang T, Li Q, Ling X (2017) Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action, did we miss something in CPT analogue molecular targets for treating human disease such as cancer

NAC has been used clinically for decades as an FDA-approved drug for acetaminophen overdose (where it replenishes hepatic glutathione) and as a mucolytic agent [18]