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More importantly, the synthesis of SAM, which requires the folate cycle, is crucial in neuropsychiatry for its role as a therapeutic agent in the treatment of depression, and as an antidepressant in Parkinsons disease (30, 65, 67)
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Examples include pernicious anemia, certain gastrointestinal surgeries, and some malabsorption syndromes
Computer modelling of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding
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