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To demonstrate the role of GSH in chemotherapy resistance, we analyzed transcriptomic data from chemotherapy patient samples in the GEO database and collected post-chemotherapy samples from patients who underwent neoadjuvant chemotherapy, assessing the expression levels of GSH and GSH synthesis-related antioxidant enzymes
Bourrie, B
Its levels drop dramatically when the toxic load is large Detoxifies many xenobiotics Chelator of lead, mercury, cadmium, and arsenic Prevents neuropathy from chemotherapy Maintains reduced state of other antioxidants: vitamin C & E Supports numerous metabolic and biochemical reactions: DNA synthesis and repair Protein synthesis Prostaglandin synthesis Amino acid transportation Enzyme activation Glutathione is a powerful antioxidant made in the bodys cells, using amino acids: glutamine, glycine, and cysteine
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