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The most frequent adverse effects are gastrointestinal and dose-related: Nausea, vomiting, diarrhoea, constipation, and abdominal discomfort - Typically worst during dose escalation and often resolve or attenuate with continued treatment and slower titration

When the mitochondrial membranes are protected from further oxidative damage, they can begin to repair themselves and resume the efficient production of ATP, slowly restoring the body's energy reserves

Blood Pressure Reduction Moderate Research Analysis of REDEFINE 1 data published in Hypertension demonstrated that CagriSema produced significant systolic blood pressure reductions of 10.9 mmHg compared to placebo at 68 weeks

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