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For example, a 12-month study in older adults found MK-677 raised IGF-1 to youthful levels and increased lean body mass , with participants gaining muscle instead of losing it all with no serious side effects noted

80,102 Very interestingly, CD38-KO mice showed increased longevity and were protected against NAD level decreases associated with age, indicating that other NAD-consuming enzymes may play an important role in age- and age-dependent diseases

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