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GHK-Cu was identified in human plasma, and its concentration declines with age
System Xc is a membrane-bound amino acid antiporter composed of solute carrier family 7 member 11 (SLC7A11) and solute carrier family 3 member 2 (SLC3A2), connected via disulfide bonds
Hardie LJ, Briggs JA, Davidson LA, Allan JM, King RF, Williams GI, Wild CP
This is because the coordination state of the copper ions in the GHK-Cu and the tripeptide is crucial to its efficacy, and acidic substances can easily dissociate the copper ions in the complex, which will reduce the activity of superoxide dismutase