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Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials[J]
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This complexity further prolongs the development process by 1824 months versus single-agent programs and raises manufacturing expenses by an estimated 35-45% relative to manufacturing expenses of GLP-1 monotherapy, which can be a challenge in price-sensitive regions
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