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Some folks like bodybuilders and athletes report enhanced muscle mass and strength

AOD-9604 + CJC-1295 + Ipamorelin is sold strictly for laboratory and research purposes and is not approved by the FDA or other regulators for human use

While it is not "mandatory" in the sense that the supplements won't work without it, Vitamin C is highly recommended as a co-factor

Surg Neurol Int 2015;6(suppl 27):S661S667

The shared biological properties of exendin-4 and human GLP-1 probably stem from their primary and secondary structures, but exendin-4 is naturally resistant to degradation by the DPP-4 enzyme, attributed to the presence of glycine at position 2, resulting in an intravenous half-life of approximately 30 minutes (85)