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Redox reactions Glutathione participates in redox reactions, neutralizing free radicals and preventing cellular damage caused by oxidative stress

Previous studies have noted that overexpression of CAT can protect tissues against oxidative insults (Shen et al., 2012

Inhibition of autophagy abrogates TMAO-induced degradation of SERCA2a and attenuates cardiac hypertrophy in vivo Firstly, to further investigate whether autophagy degradation of SERCA2a is involved in TMAO-induced cardiac hypertrophy in vivo, we administered TMAO or vehicle to mice and subsequently injected 3MA intraperitoneally for a duration of 2 weeks prior to sacrifice

Combining the two requires medical supervision for appropriate dosing and monitoring

Joore et al., 2025)