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When stimulated simultaneously, the two receptors produce a synergistic GH pulse that substantially exceeds what either compound generates alone an effect documented in the broader GHRH + GHRP literature going back to the 1990s

However, the weight loss side effect has been shown to benefit people without Type 2 diabetes as well

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Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity - Diabetes, Obesity & Metabolism Dosing schedule - Ozempic Once-Weekly Semaglutide in Adults with Overweight or Obesity - New England Journal of Medicine Weight Loss Outcomes Associated With Semaglutide Treatment for Patients With Overweight or Obesity - JAMA Semaglutide 24 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial - Lancet

Because apparent clearance was 3441% lower in the youngest/lightest children, a weight-based (mg/kg) regimen was selected to achieve comparable systemic exposure across all ages and weights and for getting the target (about 4073% across bands) compared to placebo