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95% CI, 0.84-1.2

The 2025 meta-analysis by Alfalasi and colleagues, published via PMC, synthesized data from 16 studies and 6,098 total participants

Multiple in vitro studies have demonstrated that NAC actively induces the non-immunological degranulation of mast cells, causing them to dump pre-formed histamine directly into the bloodstream, which can trigger immediate allergic-type symptoms

The key takeaways about glutathione IV therapy include its regulatory limitations, growing market demand, and mixed evidence for different health goals