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Additionally, AMG133 has an extended pharmacokinetic profile with a half-life of up to 9.1 days in obese monkeys, suitable for less frequent dosing regimens (50)

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Measurement of Matric Metalloproteinase Activity (MMP-2 and MMP-9) Matric metalloproteinase (MMP)-2 and MMP-9 activities were quantified using commercially available kits (AnaSpec) according to the manufacturers guidelines

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