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Moreover, compromised intestinal barrier integrity and gut-derived microbial components such as LPS activate TLR/NF-B/NLRP3 pathways, which not only drive systemic inflammation but also modulate gut-derived tryptophan metabolism and serotonin synthesis, thereby coupling immune regulation with neuromodulatory functions
Whether the benefit holds in patients with no residual inflammatory lesions is the question long-term data will need to answer
Chronic oxidative stress caused by adrenal hormone abnormalities may weaken the immune system (101)
Metformin Those with prediabetes, insulin resistance or polycystic ovary syndrome (PCOS) might consider this medication, she shares
However, further investigations, such as a thyroid test, may be warranted
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