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Efficacy of 42 pharmacologic cotreatment strategies added to antipsychotic monotherapy in schizophrenia: systematic overview and quality appraisal of the meta-analytic evidence

It was originally reported after isolation from rabbit blood, but its precise endogenous precursor and physiological role remain unresolved

To exemplify, aripiprazole and risperidone have proven useful for controlling irritability, aggression and emotional dysregulation, compared to placebo (Salazar, et al., 2023)