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For unregulated peptides, however, theres simply not enough evidence to say if theyre safe or not

[3] Metformin is frequently used off-label for polycystic ovary syndrome (PCOS) and in specific high-risk individuals with prediabetes (particularly those under 60, with BMI 35 kg/m, prior gestational diabetes, or rising A1C despite lifestyle interventions)

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"I think what's going on here is the advisory committee may be stacked with people who are known to have certain viewpoints on a topic rather than who are coming at this in an unconflicted and unbiased way," says Dr