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Meta analysis shows that TZDs treatment significantly reduces bone density in the forearm, lumbar spine, and total hip joints, and this effect is irreversible even after stopping TZDs for one year (15)

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Cyanocobalamin contains a cyanide molecule instead of a methyl group, making it inactive and potentially harmful

Given it currently costs in the region of 200 per month to obtain these drugs privately [19], those with the financial means may have greater access to treatment, potentially exacerbating health inequalities

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