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While classical factors such as estrogen deficiency, cellular senescence, and immune dysregulation contribute to bone loss, they often converge on or exacerbate oxidative and inflammatory pathways

Common minor side effects include temporary injection site reactions (redness, mild swelling, discomfort), occasional mild gastrointestinal effects, temporary headaches during initial treatment, and potential mild detoxification symptoms as cellular toxin mobilization increases

At 200 mcg per dose, that is only 10 doses per vial

Smith contributed equally to this work

This observation was supported by TUNEL staining, which demonstrated a more extensive area of apoptosis in the BNCT H and BNCT L/Dox@vesicles groups than in the control group, with the BNCT L group also showing apoptosis